- Esophagitis
- NSAID induced gastric ulcers
- Gastrointestinal disorder
- Peptic ulcer disease
- Bacterial infections of helicobacter pylori
Mechanism of Action-
It is a prodrug and is only activated in the acid environment by protonation and shows its activity by binding with the cysteine group of the H+K+ATPase pump on the surface of parietal cell.
Pharmacokinetics-
Absorption-
It is absorbed orally
Protein Binding-
It is 97% bound to plasma proteins
Metabolism-
It is metabolized in the liver
Excretion-
It is excreted via urine
- Headache
- Feeling sick
- Constipation
- Itching
- Skin rashes
- Dizziness
- Tiredness
- Contraindicated in osteoporosis
- Contraindicated in severe liver disease
- Ampicillin
- Nelfinavir
- Ketoconazole
- Rilpivirine